It is common knowledge that obesity is closely associated with the risk of diabetes, heart disease, hypertension, and stroke. However, the effect of obesity is not to stop there because obesity is also closely linked with asthma.
Researchers say the gene is associated with chronic inflammation in asthma could be more active in people who are obese. Study author, Paresh Dandona, MD, PhD, said that his research suggests a solution to overcome asthma in the obese patients through weight loss.
The study involved two related studies is the comparison between the obese and normal-weight people. Such an experiment to see how the behavior of biological indicators including asthma genes that changed when unhealthy obese patients perform gastric bypass surgery.
In the comparative study, the results showed that the four genes are associated with chronic inflammation in asthma is more active in obese people and obese is not healthy. Highest gene activity found in obese people who are not healthy.
The increasing number of genes is noteworthy because it can cause white blood cells called mononuclear cells produce inflammatory factors with larger quantities. Inflammatory factors such as interleukin 4, light, and lymphotoxin beta receptor contribute to allergic inflammation and other abnormalities in the bronchial tract in asthma.
Researchers also found higher concentrations of the two compounds in the blood of obese patients asthma and obesity is unhealthy. The compound is MMP-9 are associated with inflammation and nitric oxide metabolites (NOM), which is an indicator of oxidative stress.
Once a patient is obese is not healthy gastric bypass surgery, MMP-9 and NOM levels down. In addition, genes associated with asthma that interleukin 4, light, lymphotoxin beta and interleukin 33 levels are also lower in line with weight loss. With berukrangnya weight, diabetes risk was vanishingly small.
"This is the first study we are looking at the relationship between obesity and asthma through biological or immunological mechanisms," said Dandona, who served as chief of Endocrinology, Diabetes and Metabolism at the University at Buffalo, as reported by Medindia on Friday (07/19/2013).
He added that there had been no previous studies of biological explanations, giving a mechanical explanation of the fact that obesity can raise the diaphragm and can reduce lung volume.
According to him, this study could form the link between type 2 diabetes, obesity, and asthma based on biological mechanisms. This is important because obesity and type 2 diabetes associated with an increase of over 100 per cent prevalence of asthma.
This study has been published online in the journal Obesity.
